Thursday, June 26, 2003
| 8:00 - 8:20 am |
Greetings and Opening Remarks
DCP Greetings and Introductions
Welcome and Prevention overview remarks
DCTD Welcome and Therapy overview remarks
NCCAM Welcome and overview remarks from complementary and alternative medicine
ODS Welcome and overview remarks on dietary supplements
Harold Seifried
Peter Greenwald
Ellen Feigal
Steve Straus
Paul Coates |
| 8:20 - 8:55 am | Free Radicals, Cancer Prevention and Therapy:
Oxidants, Antioxidants, and Degenerative Disease
Bruce Ames |
| 8:55 - 9:05 am | Discussion |
| 9:05 - 11:30 am | Session 1 - Oxidative Stress - Positive and Negative Aspects
Chair: Steve Zeisel, University of North Carolina
(15 minute presentations followed by 5 minutes of discussion) |
| 9:05 - 9:25 am | Redox Regulation in Normal and Neoplastic Tissue
Frank Meyskens (UC Irvine, Chao Family Comprehensive Cancer Center) |
| 9:25 - 9:45 am | Cellular Responses to Oxidative Stress: Signaling for Suicide and
Survival
Nikki Holbrook (Yale University) |
| 9:45 - 10:05 am | Break |
| 10:05 - 10:25 am | Mechanisms of Pro- and Anti-oxidation
Homer S Black (Baylor) |
| 10:25 - 10:45 am | Iron, Free Radicals and Oxidative Injury
Joe M McCord (University of Colorado Health Sciences Center) |
| 10:45 - 11:05 am | Oxidative Stress and Human Genetic Variation Ralf Morgenstern (Karolinska Institutet) |
| 11:05 - 11:30 am | Discussion Session 1 |
| 11:30 - 12:30 am | Lunch |
| 12:30 - 2:00 pm | Session 2 - Antioxidant Effects Pros and Cons
Chair: Richard Rivlin, IFCP
(15 minute presentations followed by 5 minutes of discussion) |
| 12:30 - 12:50 pm | Phytochemical Effects Beyond Antioxidation David Heber (UCLA) |
| 12:50 - 1:10 pm | Tumor Suppressing Effects of Antioxidants
Roderick Dashwood (Linus Pauling Institute - Oregon State University) |
| 1:10 - 1:20 pm | Antioxidants Suppress Apoptosis
Steve Zeisel (University of North Carolina) |
| 1:20 - 1:40 pm | Mechanisms of action of tea polyphenols
CS Yang (Rutgers) |
| 1:40 - 2:00 pm | Antioxidants Enhance the Effect of Radiation and Chemotherapeutic
Agents on Cancer Cells
Kedar Prasad (University of Colorado Health Sciences Center) |
| 2:00 - 2:20 pm | Discussion Session 2 |
| 2:20 - 2:40 pm | Break |
| 2:40 - 5:00 pm | Session 3 - Biomarkers
Chair: Steve Clinton, Ohio State University
(15 minute presentation followed by 5 minutes of discussion) |
| 2:40 - 3:00 pm | Biomarkers: Fact and Artifact
James Swenberg (University of North Carolina) |
| 3:00 - 3:20 pm | Plasma Antioxidant Measurements
Ronald Prior (Arkansas Human Nutrition Center) |
| 3:20 - 3:40 pm | DNA Oxidation Products
Henry Thompson (Colorado State University) |
| 3:40 - 4:00 pm | Use of Biomarkers of Oxidative Stress in Research Studies
Jeffrey Blumberg (Tufts) |
| 4:00 - 4:20 pm | Antioxidant Enzymes - Genetic Variation
Daret St Clair (University of Kentucky) |
| 4:20 - 5:00 pm | Discussion Session 3 |
| 5:30 - 9:00 pm | Reception (Bethesda Marriott, Pooks Hill) (Poster Session) |
Friday, June 27, 2003
| 8:00 - 9:40 am | Session 4 - Clinical Aspects of Antioxidant Usage
Chair: Rebecca Costello, ODS
(15 minute presentations followed by 5 minutes of discussions) |
| 8:00 - 8:20 am | Consumer Perspectives About Antioxidants
Cheryl Toner (IFIC) |
| 8:20 - 8:40 am | What Patients Are Asking About Supplements
Cheryl Rock, (UCSD) |
| 8:40 - 9:00 am | Efficacy of Dietary Antioxidants to Prevent Oxidative Damage
Balz Frei (Linus Pauling Institute - Oregon State University) |
| 9:00 - 9:20 am | Biomarkers for Assessing Intakes of Antioxidant Nutrients
Susan T Mayne (Yale University) |
| 9:20 - 9:40 am | Discussion Session 4 |
| 9:40 - 11:30 am | Session 5a - Chemotherapy - Antioxidant Interactions
Chair: David S Rosenthal, Harvard
(15 minute presenations followed by 5 minutes of discussions) |
| 9:40 - 10:10 am | Chemotherapy, Free Radicals and Cancer: An Overview
Kenneth Conklin (UCLA) |
| 10:10 - 10:30 am | Vitamin C, Oxidative Stress, and Cancer Therapy
David Golde (MSKCC) |
| 10:30 - 10:50 am | Break |
| 10:50 - 11:10 am | Drugs, Glutathione and ROS in Regulation of Proliferation
Kenneth D Tew (Fox Chase) |
| 11:10 - 11:30 am | Discussion Session 5 |
| 11:30 - 12:50 pm | Session 5b - Radiotherapy - Antioxidant Interactions
Chair: Norman Coleman, NCI
(15 minute presentations followed by 5 minutes of discussion) |
| 11:30 - 11:50 pm | Radiotherapy, Free Radicals and Cancer
Carmia Borek (Tufts) |
| 11:50 - 12:10 pm | Novel Functional Imaging for Tissue Oxygen Concentration and Redox
Status
James Mitchell (NCI) |
| 12:10 - 12:30 pm | Prostate Cancer Therapy and Biomarkers
William Nelson (Johns Hopkins) |
| 12:30 - 1:30 pm | Lunch |
| 1:30 - 1:50 pm | Redox Sensitive Signaling Factors and Antioxidants: How Tumor Cells
Response to Ionizing Radiation
David Gius (NCI) |
| 1:50 - 2:10 pm | Discussion Session 5 |
| 2:10 - 3:30 pm | Session 6 - Wrap-up/Summary, Opportunities and Challenges
Chair: John Milner
Panel Members: Drs Clinton, Zeisel, Rivlin, Rosenthal |
