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Programs & Resources
Tenth EDRN Steering Committee Meeting

Agenda

Monday, March 21, 2005
TimeTopic
8:30 am - 3:30 pm Orientation Meeting for BRLs, CEVCs, and DMCC
10:00 am - 3:00 pm Proteomic Interest Group Meeting
12:30 - 1:30 pmHands on Training - EDRN Informatics
3:00 - 6:00 pmGenomic/Epigenomic Interest Group Meeting
3:30 - 4:30 pmHands on Training - EDRN Informatics
6:30 - 7:00 pmLobby/Registration
7:00 - 7:15 pmWelcome
Sudhir Srivastava, PhD, National Cancer Institute
David Sidransky, MD, Johns Hopkins University School of Medicine
7:15 - 7:30 pmAdvocacy Group Presentation
Ellen V Sigal, PhD, Chair, Friends of Cancer Research
7:30 - 8:15 pmEDRN: A Reflection on Networking Experience
Moderator: Padma Maruvada, PhD, National Cancer Institute

Biomarker Discovery
Samir Hanash, MD, PhD, Fred Hutchinson Cancer Research Center

Clinical Validation of Biomarkers
Zhen Zhang, PhD, Johns Hopkins University

EDRN Associate Member's Viewpoint
Anna Lokshin, PhD, University of Pittsburgh

Challenges for the Future
David Sidransky, MD, Johns Hopkins University School of Medicine
8:15 - 9:30 pmCollaborative Groups & Subcommittees Roles and Responsibilities
Paul Wagner, PhD, National Cancer Institute
8:15 - 9:30 pmState-of-the-Science Breast and Gynecologic Cancers
Daniel Cramer, MD, ScD, Brigham and Women's Hospital Gastrointestinal and Other Cancers

Dean Brenner, MD, University of Michigan Lung and Upper Aerodigestive Tract Cancers

Melvyn Tockman, MD, PhD, H Lee Moffitt Cancer Center Prostate and Other Urologic Cancers

Bodgan Czerniak, MD, MD Anderson Cancer Center

Proteomic Interest Group

EDRN Proteomic Interest Group Meeting

10:00 am 3:00 pm
Moderator: Samir Hanash, MD, PhD Fred Hutchinson Cancer Research Center
NCI Program Director: Jacob Kagan, PhD, National Cancer Institute

Monday, March 21, 2005
TimeTopic
10:00 - 10:15 amObjectives
Sudhir Srivastava, PhD, National Cancer Institute
10:15 - 10:45 amEastern & Western Consortium on Mouse Proteomics Samir Hanash
10:45 - 11:15 amObstacles and Opportunities in Clinical Proteomics
David Ransohoff, MD, University of North Carolina at Chapel Hill
11:15 - 11:30 pmOverview of EDRN Proteomic Activities
Jacob Kagan
11:30 - 12:00 pmEDRN Ab Microarrays Activities through SBIR Contracts Neoclone's platform for Ab microarrays
Ward Tucker, PhD, Neoclone Biotechnology
Biomachine's platform for Ab microarrays
Christoph Borchers, PhD, University of North Carolina at Chapel Hill
12:00 - 12:30 pmDiscussion
12:30 - 1:30 pmLunch (On Your Own)
1:30 - 3:00 pmDiscussion
Moderator: Samir Hanash
Topics of Discussion:
  • Define and draft goals of the EDRN Proteomic Interest Group
  • Coordinate proteomic activities, EDRN & other consortia
  • Share standards and reference samples
  • Discuss standards for data storage and submission
  • Discuss collaborative projects for cross-technologies and cross validation
  • Schedule Proteomics Interest Group conference calls and meetings
  • Other issues
3:00 pmAdjourn

Genomic/Epigenomic Interest Group

EDRN Proteomic Interest Group Meeting

3:00 - 6:00 pm
Moderators: Stephen Meltzer, MD, University of Maryland School of Medicine
Jacob Kagan, PhD, National Cancer Institute

Monday, March 21, 2005
TimeTopic
3:00 - 3:10 pmObjectives
Sudhir Srivastava, PhD, National Cancer Institute
3:10 - 3:30 pmEpigenomic Signatures in the GI Tract
Stephen Meltzer, MD, University of Maryland School of Medicine
3:30 - 4:00 pmWhat's new in methylation: Gene discovery, application and risk assessment
Adi Gazdar, MD, UT Southwestern Medical Center
4:00 - 4:45 pmHigh Throughput Platforms for Methylation Studies
David Sidransky, MD, Johns Hopkins University
  • QMSP: TBA
  • Sequenome TBA
  • Other chip technology: TBA
4:45 - 6:00 pmDiscussion
Moderator: Stephen Meltzer, MD, University Maryland
Topics of Discussion:
    Methodologic Controversies and Criteria
  • Collaborative Projects for Cross-technologies and Cross-Validation Reference Tissues and Body Fluids for Methylation studies
  • Sharing of Standards and Reference Samples
  • Standards for Data Storage and Submission Conference Calls and Meetings

Other issues
6:00 pmAdjourn

Tuesday, March 22, 2005
TimeTopic
7:00 - 8:00 amLobby/Registration
8:00 - 8:15 amOpening of Steering Committee Meeting
David Sidransky, MD, EDRN Steering Committee Chair

Discussion: Future EDRN Steering Committee Meetings
  • September, 2005
  • March, 2006
  • September, 2006
  • March, 2007
  • September, 2007
8:15 - 8:20 amWelcome Peter Greenwald, MD, DrPh, National Cancer Institute
8:20 - 8:45 amState-of-the-EDRN
Sudhir Srivastava, PhD, National Cancer Institute
8:45 - 9:00 amCancer Biomarker Metrology: A Fundamental Measurement Problem
Robert N Goldberg, PhD, National Institute for Standards and Technology
9:00 - 10:00 amPresentations from New BDL, BRL and CEVC Members
Moderator: Karl Krueger, PhD, National Cancer Institute
10:00 - 10:15 amBreak
10:15 - 11:30 amPresentations from New BDL, BRL and CEVC Members
11:30 am - 1:00 pmLunch
1:00 - 3:00 pmMini Workshop: Translating Biomarkers into Clinical Application: Topic: Toolkits for Validation
Moderators: Jacob Kagan, PhD, National Cancer Institute and DMCC Staff

Speakers: What Constitutes a Good Validation Study Proposal?
Ziding Feng, PhD, Fred Hutchinson Cancer Research Center (DMCC)

Practical Considerations in Development of Clinical Trials
Ian Thompson, MD, University of Texas Health Science Center at San Antonio

Topic: Protocol Implementation
Moderators: Jacob Kagan, PhD and DMCC Staff

Speakers: DCP Study
Jorge Marrero, MD, University of Michigan MSA Study

Mark Thornquist, PhD, Fred Hutchinson Cancer Research Center (DMCC)

SELDI Study
John Semmes, PhD, Eastern Virginia Medical School
3:00 - 5:00 pmCollaborative Group Meetings (By Invitation Only)

GI and Associated Cancers Collaborative Group
Chair: Dean Brenner

Breast/Gynecological Cancers Collaborative Group
Chair: Daniel Cramer

Prostate and other Urologic Cancers Collaborative Group
Bogdan Czerniak

Lung and Upper Aerodigestive Cancers Collaborative
Group Chair: Melvyn Tockman
5:00 - 6:00 pmElection/Appointment of Chairs (Steering Committee Principal Investigators Only)
Moderator: Sudhir Srivastava
6:00 - 7:30 pmDinner
7:30 - 9:30 pmSubcommittee Meetings Collaboration and Publication Subcommittee
Chair: David Fishman

Communication and Workshop Subcommittee
Chair: William Rom

Technology and Resource Sharing Subcommittee
Chair: Timothy Block

Prioritization Subcommittee
Chair: William Bigbee

Data Sharing and Informatics Subcommittee
Chair: Mark Thornquist

Wednesday, March 23, 2005
TimeTopic
7:00 - 8:00 amContinental Breakfast
8:00 - 8:15 amWrap up of Days 1 & 2 of Steering Committee Meeting
Melvyn Tockman, MD, PhD, H Lee Moffitt Cancer Center
8:15 - 8:45 amStrategic Initiatives at NCI
Anna Barker, PhD, National Cancer Institute
8:45 - 10:00 amPanel Discussion: How to Accelerate Biomarkers from Discovery to Development to Validation?
Moderators: Laura Esserman, MD, MBA, UCSF Medical Center
Wendy Wang, PhD, MSc, National Cancer Institute

Panelists: Drs Daniel Cramer, Paul Engstrom, Ziding Feng, Samir Hanash, Stephen Meltzer and Ian Thompson Topics of Discussion (10 minutes each):
  • Bottlenecks: Biomarker discovery or validation or both? Paul Cairns, PhD, Fox Chase Cancer Center
  • Overcoming Bottlenecks: Ways to synergize efforts within and outside the EDRN William Grizzle, MD, PhD, University of Alabama at Birmingham
  • Biomarker Reference Set Dean Brenner, MD, University of Michigan
10:00 - 10:15 amBreak
10:15 - 11:00 amFuture Plans for Informatics Resources Secure Site Resources
Mark Thornquist, PhD, Heather Kincaid, Fred Hutchinson Cancer Research Center (DMCC)
Dan Crichton, NASA Jet Propulsion Laboratories

Public Portal
Mark Thornquist, PhD, Heather Kincaid, Fred Hutchinson Cancer Research Center (DMCC)
Dan Crichton, NSA Jet Propulsion Laboratories
Donald Johnsey, National Cancer Institute
11:00 - 11:45 amCollaborative Group Reports
11:45 am - 12:30 pm Subcommittee & Liaison Reports
12:30 - 1:30 pmLunch
12:30 - 1:30 pmEC Meeting (Working Lunch) by Invitation Only
1:30 - 3:30 pmOther Biomarkers Initiatives
NCI Biomarker Discovery Program
Greg Downing, DO, PhD, National Cancer Institute

Program Announcements: RFA-CA-06-001 & PA-04-035: Circulating Cells and DNA in Cancer Detection
Padma Maruvada, PhD, National Cancer Institute

Program Announcement: PA-05-048: Protein Biomarkers of Infection-Associated Cancers
Karl Krueger, PhD, National Cancer Institute

Summary of Proteomic Interest Group
Samir Hanash, MD, PhD, Fred Hutchinson Cancer Research Center

Mouse Model Consortium
Cheryl Marks, PhD, National Cancer Institute

EDRN-SPORE Lung Cancer Proteome Initiative
Sudhir Srivastava, PhD, National Cancer Institute

Integrative Biology Consortium
Daniel Gallahan, PhD, National Cancer Institute
3:30 - 4:00 pmClosing Comments
4:00 pmAdjorn


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