Skip to content
National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
Division of Cancer Prevention logo
Home Site Map Contact DCP
Programs & Resources
Diet, Epigenetic Events, and Cancer Prevention Symposium

Agenda

Sponsors: Division of Cancer Prevention (DCP), National Cancer Institute (NCI), and Office of Dietary Supplements (ODS) at the National Institutes of Health (NIH)

Day 1: Wednesday, September 26, 2007
7:30 - 8:00 amRegistration and Light Refreshments
8:00 - 8:05 amWelcome
Sharon Ross, DCP, NCI
8:05 - 8:20 amOpening Remarks
Peter Greenwald, Director, DCP, NCI
Paul Coates, Director, ODS, NIH
John Milner, Chief, Nutritional Science Research Group (NSRG), DCP, NCI
8:20 - 8:55 amOverview: Epigenetic Progression of Human Lung Cancer: Early Events in the Development of Cancer
James Herman, Johns Hopkins University
8:55 - 9:05 amDiscussion
9:05 - 12:15 pmSession 1: Are There Critical Times of DNA Methylation and Potential Modification by Dietary Factors?
Moderator: Johanna Dwyer, ODS, NIH
9:05 - 9:30 amMaternal Nutrient Supplementation Counteracts Bisphenol A-Induced DNA Hypomethylation in Early Development
Dana Dolinoy, Duke University
9:30 - 9:40 amDiscussion
9:40 - 10:05 amEffects of Methyl Donors on Epigenetic Inheritance and CpG Methylation at the Avy Allele
David IK Martin, Children's Hospital Oakland Research Institute
10:05 - 10:15 amDiscussion
10:15 - 10:35 amBREAK
10:35 - 11:00 amOne-Carbon Nutrients and Age as Co-Determinants of Colorectal Carcinogenesis
Joel B Mason, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University
11:00 - 11:10 amDiscussion
11:10 - 11:35 amReversal of Hypermethylation and Reactivation of Genes by Dietary Polyphenolic Compounds
Chung S Yang, Rutgers University
11:35 - 11:45 amDiscussion
11:45 am - 12:15 pmSession 1 Group Discussion
12:15 - 1:15 pmLUNCH (on your own)
1:15 - 4:25 pmSession 2: Examining Diet and DNA Methylation Patterns in Human Population and Intervention Studies What Is Needed To Move Forward?
Moderator: Asad Umar, DCP, NCI
1:15 - 1:40 pmEpigenetic Epidemiology of Obesity: Application of Epigenomic Technologies
Robert A Waterland, Baylor College of Medicine
1:40 - 1:50 pmDiscussion
1:50 - 2:15 pmFolate, Diet, and DNA Methylation in Colonic Mucosa Jean-Pierre Issa, University of Texas at MD Anderson Cancer Center
2:15 - 2:25 pmDiscussion
2:25 - 2:50 pmDNA Methylation Biomarkers To Assess Selenium Chemoprevention for Non-Small-Cell Lung Cancer
Steven A Belinsky, Lovelace Respiratory Research Institute
2:50 - 3:00 pmDiscussion
3:00 - 3:20 pmBREAK
3:20 - 3:45 pmModeling Folate, One-Carbon Metabolism, and DNA Methylation
Cornelia M Ulrich, Fred Hutchinson Cancer Research Center
3:45 - 3:55 pmDiscussion
3:55 - 4:25 pmSession 2 Group Discussion
4:25 - 5:50 pmSession 3: What Is the Role of Non-Coding RNA in Transcriptional Gene Silencing? Is There Evidence for Diet and Bioactive Food Components To Modulate This Gene Expression Regulatory Mechanism?
Moderator: Jacob Kagan, DCP, NCI
4:25 - 4:50 pmThe Role of RNA in the Regulation of Gene Expression
Kevin V Morris, The Scripps Research Institute
4:50 - 5:00 pmDiscussion
5:00 - 5:25 pmDifferential Expression of MicroRNAs During Methyl-Deficient-Induced Rat Hepatocarcinogenesis
Igor Pogribny, US Food and Drug Administration, National Center for Toxicological Research
5:25 - 5:35 pmDiscussion
5:35 - 5:50 pmSession 3 Group Discussion
5:50 pmADJOURNMENT

Day 2: Thursday, September 27, 2007
8:30 - 11:40 amSession 4: How Strong Is the Evidence for the Impact of Diet on Histone Modification and Gene Expression?
Moderator: Mukesh Verma, Division of Cancer Control and Population Sciences, NCI
8:30 - 8:55 amDietary Agents as Histone Deacetylase Inhibitors
Roderick H Dashwood, Linus Pauling Institute, Oregon State University
8:55 - 9:05 amDiscussion
9:05 - 9:30 amIn Vivo Treatment by Diallyl Disulfide Increases Histone Acetylation in Rat Colonocytes
Nathalie Druesne-Pecollo, Laboratoire de Nutrition et Sécurité Alimentaire, L'institut National de la Recherche Agronomique
9:30 - 9:40 amDiscussion
9:40 - 10:05 amDietary Polyphenols Mediated Regulation of Oxidative Stress and Chromatin Remodeling in Inflammation
Irfan Rahman, University of Rochester Medical Center
10:05 - 10:15 amDiscussion
10:15 - 10:35 amBREAK
10:35 - 11:00 amEpigenetic Regulation of Chromatin Structure and Gene Function by Biotin: Are Biotin Requirements Being Met?
Janos Zempleni, University of Nebraska at Lincoln
11:00 - 11:10 amDiscussion
11:10 - 11:40 amSession 4 Group Discussion
11:40 - 4:45 pmSession 5: What Are the Emerging Issues and Approaches in Epigenetics Research
Moderator: Barbara Dunn, DCP, NCI
11:40 am - 12:05 pmEpigenetics Meets Diet: Applications of Epigenomic Tools in Nutrition
Tim H Huang, Ohio State University
12:05 - 12:15 pmDiscussion
12:15 - 1:15 pmLUNCH (on your own)
1:15 - 1:40 pmMouse Models To Elucidate Mechanisms of Folate-Related Cancer Pathologies
Patrick Stover, Cornell University
1:40 - 1:50 pmDiscussion
1:50 - 2:15 pmFolate, DNA Methylation Machinery, and Breast Tumorigenesis
Joshua Miller, University of California, Davis
2:15 - 2:25 pmDiscussion
2:25 - 2:50 pmThe BMI-1 Polycomb Group Gene in Skin Cancer – Regulation of Function by (-)- Epigallocatechin-3-Gallate (EGCG)
Richard L Eckert, University of Maryland School of Medicine
2:50 - 3:00 pmDiscussion
3:00 - 3:20 pmBREAK
3:20 - 3:45 pmNIH Roadmap Epigenomics Program
Brenda Weis, National Institute of Environmental Health Sciences
3:45 - 3:55 pmDiscussion
3:55 - 4:20 pmInfluence of Genetic Inheritance on Global Epigenetic States and Cancer Risk Prediction With DNA Methylation Signature: Challenges in Data Analysis and Informatics Infrastructure
Maxwell Lee, Laboratory of Population Genetics, NCI
4:20 - 4:30 pmDiscussion
4:30 - 4:45 pmSession 5 Group Discussion
4:45 - 5:00 pmSummary, Directions for Future Research, and Wrap-Up Sharon Ross, DCP, NCI
5:00 pmAdjounment


Back to top