Publications and Presentations
Journal Articles
2007
Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL. Resveratrol: A review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol, 2007, (in press).
PMID: 17306316
Chalut KJ, Kresty LA, Pyhtila JW, Nines R, Baird M, Steele VE, Wax A. In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry. Cancer Epidemiol Biomarkers Prev 16 (2): 223-7, 2007.
PMID: 17301253
Elmore E, Jain A, Siddiqui S, Tohidian N, Meyskens FL, Steele VE, Redpath JL. Development and characteristics of a human cell assay for screening agents for melanoma prevention. Melanoma Res 17 (1): 42-50, 2007.
PMID: 17235241
Pereira MA, Tao L, Liu Y, Li L, Steele VE, Lubet RA. Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int J Cancer 120 (5): 1150-3, 2007.
PMID: 17163412
Ware JH, Zhou Z, Guan J, Kennedy AR, Kopelovich L. Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents. Anticancer Res 27 (1A): 1-16, 2007.
PMID: 17352209
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2006
Ali IU, Xiao Z, Malone W, Smith M, Conrads TP, Veenstra TD, Greenwald P, Luke BT, McLarty JW. Plasma proteomic profiling: search for lung cancer diagnostic and early detection markers. Oncol Rep 15 (5): 1367-1372, 2006.
PMID:16596212
Alyaqoub FS, Tao L, Kramer PM, Steele VE, Lubet RA, Gunning WT, Pereira MA. Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT). Carcinogenesis, 2006, (in press).
PMID:16885199
Arif JM, Dresler C, Clapper ML, Gairola CG, Srinivasan C, Lubet RA, Gupta RC. Lung DNA adducts detected in human smokers are unrelated to typical polyaromatic carcinogens. Chem Res Toxicol 19 (2): 295-299, 2006.
PMID:16485906
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. Hedgehog signalling in skin development and cancer. Exp Dermatol 15 (9): 667-677, 2006.
PMID:16881963
Balansky R, D'Agostini F, Ganchev G, Izzotti A, Di Marco B, Lubet RA, Zanesi N, Croce CM, De Flora S. Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine. Proc Natl Acad Sci USA 103 (20): 7823-7828, 2006.
PMID:16672365
Boocock DJ, Patel KR, Faust GE, Normolle DP, Marczylo TH, Crowell JA, Brenner DE, Booth TD, Gescher A, Steward WP. Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, (in press).
PMID: 17097357
Brill SS, Furimsky AM, Ho MN, Furniss MJ, Li Y, Green AG, Bradford WW, Green CE, Kapetanovic IM, Iyer LV. Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. J Pharm Pharmacol 58 (4): 469-479, 2006.
PMID:16597364
Burgess JP, Wintermute JS, Thomas BF, Kapetanovic IM. Complete (1)H and (13)C assignments of fluorinated analogs of dehydroepiandrosterone. Magn Reson Chem 44 (11): 1051-3, 2006.
PMID: 16835888
Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M, Jr., Yeaman C, Camonis JH, Zhao Y, White MA. RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127 (1): 157-70, 2006.
PMID: 17018283
Chow HH, Hakim IA, Vining DR, Crowell JA, Cordova CA, Chew WM, Xu MJ, Hsu CH, Ranger-Moore J, Alberts DS. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev 15 (12): 2473-6, 2006.
PMID: 17164372
Crowell JA, Page JG, Levine BS, Tomlinson MJ, Hebert CD. Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450. Toxicol Appl Pharmacol. 211 (2): 115-123, 2006.
PMID:16043203
Gerhauser C, Bartsch H, Crowell J, Flora SD, D'Incalci M, Dittrich C, Frank N, Mihich E, Steffen C, Tortora G, Gescher A. Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising Phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005. Eur J Cancer 42 (10): 1338-1343, 2006.
PMID:16730975
Grubbs CJ, Lubet RA, Atigadda VR, Christov K, Deshpande AM, Tirmal V, Xia G, Bland KI, Eto I, Brouillette WJ, Muccio DD. Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. Carcinogenesis 27 (6): 1232-1239, 2006.
PMID:16344269
Horn TL, Cwik MJ, Morrissey RL, Kapetanovic I, Crowell JA, Booth TD, McCormick DL. Oncogenicity evaluation of resveratrol in p53((+/-)) (p53 knockout) mice. Food Chem Toxicol, 2006, (in press).
PMID:16965847
Huang Y, Yan J, Lubet R, Kensler TW, Sutter TR. Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione. Physiol Genomics 24 (2): 144-153, 2006.
PMID:16317079
Johnson WD, Dooley L, Morrissey RL, Arp L, Kapetanovic I, Crowell JA, McCormick DL. Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice. Int J Toxicol. 25 (3): 219-228, 2006.
PMID:16717037
Kapetanovic IM. Computer-aided drug discovery and development (CADDD): In silico-chemico-biological approach. Chem Biol Interact, 2006, (in press).
PMID: 17229415
Kapetanovic IM, Krishnaraj R, Martin-Jimenez T, Yuan L, van Breemen RB, Lyubimov A. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics. Chem Biol Interact, 2006, (in press).
PMID: 17027946
Kapetanovic IM, Krishnaraj R, Martin-Jimenez T, Yuan L, van Breemen RB, Lyubimov A. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics. Chem Biol Interact 164 (1-2): 68-75, 2006.
PMID: 17027946
Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M. Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways. Exp Dermatol 15 (7): 538-546, 2006.
PMID:16761963
Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6: 10, 2006.
PMID:16545122
Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, You M. A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. Cancer Res 66 (4): 1956-1963, 2006.
PMID:16488994
Lubet RA, Christov K, You M, Yao R, Steele VE, End DW, Juliana MM, Grubbs CJ. Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations. Mol.Cancer Ther 5 (4): 1073-1078, 2006.
PMID:16648579
McCormick DL, Johnson WD, Kozub NM, Rao KV, Lubet RA, Steele VE, Bosland MC. Chemoprevention of rat prostate carcinogenesis by dietary 16{alpha}-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone. Carcinogenesis, 2006, (in press).
PMID:16952912
Mehta SA, Christopherson KW, Bhat-Nakshatri P, Goulet RJ, Jr., Broxmeyer HE, Kopelovich L, Nakshatri H. Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. Oncogene, 2006, (in press).
PMID: 17130833
Ouyang N, Williams JL, Tsioulias GJ, Gao J, Iatropoulos MJ, Kopelovich L, Kashfi K, Rigas B. Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. Cancer Res. 66 (8): 4503-4511, 2006.
PMID: 16618778
Pereira MA, Kramer PM, Nines R, Liu Y, Alyaqoub FS, Gunning WT, Steele VE, Lubet RA. Prevention of mouse lung tumors by targretin. Int J Cancer 118 (9): 2359-2362, 2006.
PMID:16331605
Rao CV, Reddy BS, Steele VE, Wang CX, Liu X, Ouyang N, Patlolla JM, Simi B, Kopelovich L, Rigas B. Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. Mol Cancer Ther 5 (6): 1530-1538, 2006.
PMID:16818512
Reddy BS, Wang CX, Kong AN, Khor TO, Zheng X, Steele VE, Kopelovich L, Rao CV. Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats. Cancer Res 66 (8): 4542-4546, 2006.
PMID:16618783
Reed GA, Arneson DW, Putnam WC, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Cancer Epidemiol Biomarkers Prev 15 (12): 2477-81, 2006.
PMID:17164373
Sharma S, Gao P, Steele VE. The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. Carcinogenesis 27 (8): 1721-1727, 2006.
PMID:16632869
Steele VE, Arnold JT, Lei H, Izmirlian G, Blackman MR. Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells. Anticancer Res 26 (5A): 3205-15, 2006.
PMID: 17094431
Swamy MV, Patlolla JM, Steele VE, Kopelovich L, Reddy BS, Rao CV. Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. Cancer Res 66 (14): 7370-7377, 2006.
PMID:16849589
Verschoyle RD, Greaves P, Cai H, Borkhardt A, Broggini M, D'Incalci M, Riccio E, Doppalapudi R, Kapetanovic IM, Steward WP, Gescher AJ. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Cancer Chemother.Pharmacol. 57 (1): 1-6, 2006.
PMID:16001171
Wang Y, Yao R, Maciag A, Grubbs CJ, Lubet RA, You M. Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. Mol Cancer Ther 5 (4): 1060-1072, 2006.
PMID:16648578
Wang Y, Zhang Z, Lubet RA, You M. A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. Oncogene 25 (8): 1277-1280, 2006.
PMID:16247444
Wang Y, Zhang Z, Yao R, Jia D, Wang D, Lubet RA, You M. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene 25 (9): 1320-1329, 2006.
PMID:16247446
Ware JH, Zhou Z, Kopelovich L, Kennedy AR. Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell line. Anticancer Res 26 (6B): 4177-83, 2006.
PMID:17201130
Woditschka S, Haag JD, Waller JL, Monson DM, Hitt AA, Brose HL, Hu R, Zheng Y, Watson PA, Kim K, Lindstrom MJ, Mau B, Steele VE, Lubet RA, Gould MN. Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. Cancer Res 66 (13): 6884-6891, 2006.
PMID:16818667
Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M. Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. Mol Cancer Res 4 (12): 971-81, 2006.
PMID:17189387
Yan Y, Wang Y, Tan Q, Hara Y, Yun TK, Lubet RA, You M. Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. Neoplasia 8 (1): 52-58, 2006.
PMID:16533426
Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M. Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: Role of Ha-ras mutations and use of microarray analysis to identify potential targets. Carcinogenesis 27 (7): 1420-31, 2006.
PMID:16403772
Zhang Z, Wang Y, Yao R, Li J, Lubet RA, You M. p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. Mol Cancer Res 4 (6): 401-410, 2006.
PMID:16778087
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2005
Catz P, Shinn W, Kapetanovic IM, Kim H, Kim M, Jacobson EL, Jacobson MK, Green CE: Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chrom. B Analyt Technol Biomed Life Sci. 829:123-35, 2005. [Abstract on PubMed]
Crist, K.A., Zhang, Z., You, M., Gunning, W.T., Conran, P.B., Steele, V.E., and Lubet R.A. Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethyldenz[a]anthracene (DMBA) coated suture. Carcinogenesis 26:951-957, 2005. [Abstract on PubMed]
Elmore, E., Siddiqui, S., Navidi, M., Steele, V.E., and Redpath, L. Correlation of In Vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels. J Cell Biochem, 95:571-588, 2005. [Abstract on PubMed]
Horn TL, Long L, Cwik MJ, Morrissey RL, Kapetanovic IM, McCormick DL: Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. Chemico-Biol. Interact. 152:79-99, 2005. [Abstract on PubMed]
Lubet, R.A., Christov, K., Nunez, N.P., Hursting, S.D., Steele, V.E., Juliana, M.M., Eto, I., Grubbs, C.J. Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis. Carcinogenesis. 26(2):441-448, 2005. [Abstract on PubMed]
Lubet, R.A., Huebner, K., Fong, L.Y.Y., Altieri, D.C., Steele, V.E., Kopelovich, L., Kavanaugh, C., Juliana, M.M., Soong, S., and Grubbs, C.J. N-Butyl-N(4 hydroxybutyl)-nitrosamine (OH-BBN) - induced urinary bladder cancers in mice: Characterization of FHIT, survivin expression, and chemoprevention effects of indomethacin. Carcinogenesis 26(3): 571-578, 2005. [Abstract on PubMed]
Raju, J., Swamy, M.V., Cooma, I., Patlolla, J.M.R., Pittman, B., Reddy, B.S., Steele, V.E., and Rao, C.V. Low doses of beta-carotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidence. Int J Cancer. 113(5):798-802, 2005. [Abstract on PubMed]
Simeone, A-M, Deng, C-X, Kelloff, G.J., Steele, V.E., Johnson, M.M., and Tari, A.M. Inhibitory effects of N-(4-hydroxyphenyl)retinamide and other phenylretinamides against BRCA-1 mutated breast cancer cells. Carcinogenesis, 26:1000-1007, 2005.
[Abstract on PubMed]
Wax, A., Pyhtila, J.W., Graf, R.N. Graf, Nines, R., Boone, C.W., Dasari, R.R., Feld, M.S., Steele, V.E., and Stoner, G.D. Prospective grading of neoplastic change in rat esophagus using angle-resolve low coherance interferometry. Journal of Miomedical Optics 10(5): 051604-01-10, 2005. [Abstract on PubMed]
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2004
Almahmeed T, Boyle JO, Cohen EG, Carew JF, Du B, Altorki NK, Kopelovich L, Fang JL, Lazarus P, Subbaramaiah K, Dannenberg AJ. (2004) Benzo[a]pyrene phenols are more potent inducers of CYPlAl, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis. Jan 16
[Abstract on PubMed]
Bonner AE, Lemon WJ, Devereux TR, Lubet RA, You M. (2004) Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Oncogene. Feb 5;23(5):1166-76.
[Abstract on PubMed]
Cope MB, Steele VE, Lubet RA, Eto I, Juliana MM, Hill DL, Grubbs CJ. (2004) Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention. Oncol Rep. Feb;11(2):465-9.
[Abstract on PubMed]
Estensen RD, Jordan MM, Wiedmann TS, Galbraith AR, Steele VE, Wattenberg LW. (2004) Effect of chemopreventive agents on separate stages of progression of benzo[a]pyrene induced lung tumors in A/J mice. Carcinogenesis. Feb;25(2):197-201.
[Abstract on PubMed]
Kapetanovic IM, Rosenfeld S, Izmirlian G: Overview of commonly used bioinformatics methods and their applications. In: Umar A, Kapetanovic IM, Khan J (eds) The Applications of Bioinformatics in Cancer Detection, Annals of the New York Academy of Sciences, New York, New York, 1020: 10-21, 2004.
Kapetanovic IM, Umar A, Khan J: Proceedings of the applications of bioinformatics in cancer detection (ABCD) workshop. In: Umar A, Kapetanovic IM, Khan J (eds) The Applications of Bioinformatics in Cancer Detection, Annals of the New York Academy of Sciences, New York, New York, 1020: 1-9, 2004.
Posner GH, Jeona HB, Sarjeanta A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Sahad U, Dolane P, Kensler TW: Low-calcemic, efficacious, 1_,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry. Steroids 69: 757-762, 2004.
Tao L, Wang W, Kramer PM, Lubet RA, Steele VE, Pereira MA. (2004) Modulation of DNA hypomethylation as a surrogate endpoint biomarker for chemoprevention of colon cancer. Mol Carcinog. Feb;39(2):79-84.
[Abstract on PubMed]
Umar A, Kapetanovic IM, Khan J (eds) The Applications of Bioinformatics in Cancer Detection, Annals of the New York Academy of Sciences, New York, New York, v. 1020, pp. 1-277, 2004.
Williams JL, Kashfi K, Ouyang N, del Soldato P, Kopelovich L, Rigas B. (2004) NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice. Biochem Biophys Res Commun. Jan 16;313(3):784-8.
[Abstract on PubMed]
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2003
Balansky RM, Izzotti A, D'Agostini F, Camoirano A, Bagnasco M, Lubet RA, De Flora S. (2003) Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice. Carcinogenesis. Sep;24(9):1525-32.
[Abstract on PubMed]
Chang PY, Mirsalis J, Riccio ES, Bakke JP, Lee PS, Shimon J, Phillips S, Fairchild D, Hara Y, Crowell JA. (2003) Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E. Environ Mol Mutagen. 41(1):43-54.
[Abstract on PubMed]
Chow HH, Cai Y, Hakim IA, Crowell JA, Shahi F, Brooks CA, Dorr RT, Hara Y, Alberts DS. (2003) Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. Aug 15;9(9):3312-9.
[Abstract on PubMed]
Christov K, Ikui A, Shilkaitis A, Green A, Yao R, You M, Grubbs C, Steele V, Lubet R, Weinstein IB. (2003) Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors. Breast Cancer Res Treat. 77(3):253-64.
[Abstract on PubMed]
Christov KT, Shilkaitis AL, Kim ES, Steele VE, Lubet RA. (2003 ) Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours. Eur J Cancer. 39(2):230-9.
[Abstract on PubMed]
Crowell JA, Steele VE, Sigman CC, Fay JR. (2003) Is inducible nitric oxide synthase a target for chemoprevention? Mol Cancer Ther. Aug;2(8):815-23.
[Abstract on PubMed]
Crowell JA, Steele VE. (2003) AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment. J Natl Cancer Inst. 95(4):252-3.
[No abstract available.]
Decensi A, Veronesi U, Miceli R, Johansson H, Mariani L, Camerini T, Di Mauro MG, Cavadini E, De Palo G, Costa A, Perloff M, Malone WF, Formelli F. (2003) Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide. Clin Cancer Res. Oct 15;9(13):4722-9.
[Abstract on PubMed]
De Flora S, Balansky RM, D'Agostini F, Izzotti A, Camoirano A, Bennicelli C, Zhang Z, Wang Y, Lubet RA, You M. (2003) Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke. Cancer Res. 63(4):793-800.
[Abstract on PubMed]
De Flora S, D'Agostini F, Balansky R, Camoirano A, Bennicelli C, Bagnasco M, Cartiglia C, Tampa E, Longobardi MG, Lubet RA, Izzotti A. (2003) Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis. Mutat Res. 523-524:237-52.
[Abstract on PubMed]
Ding H, Han C, Gibson-D'Ambrosio R, Steele VE, D'Ambrosio SM. (2003) Piroxicam selectively inhibits the growth of premalignant and malignant human oral cell lines by limiting their progression through the S phase and reducing the levels of cyclins and AP-1. Int J Cancer. Dec 10;107(5):830-6.
[Abstract on PubMed]
Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, Crowell JA, Stacewicz-Sapuntzakis M, Bowen PE. (2003) A physiological pharmacokinetic model describing the disposition of lycopene in healthy men. J Lipid Res. Oct;44(10):1927-39.
[Abstract on PubMed]
Fischer SM, Conti CJ, Viner J, Aldaz CM, Lubet RA. (2003) Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis. May;24(5):945-52.
[Abstract on PubMed]
Gunning WT, Kramer PM, Lubet RA, Steele VE, End DW, Wouters W, Pereira MA. (2003) Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777. Clin Cancer Res. May;9(5):1927-30.
[Abstract on PubMed]
Herbert BS, Pearce VP, Hynan LS, LaRue DM, Wright WE, Kopelovich L, Shay JW. (2003) A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells. Cancer Res. Apr 15;63(8):1914-9.
[Abstract on PubMed]
Hu Z, Bonifas JM, Aragon G, Kopelovich L, Liang Y, Ohta S, Israel MA, Bickers DR, Aszterbaum M, Epstein EH Jr. (2003) Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors. Cancer Res. 63(5):923-8.
[Abstract on PubMed]
Kopelovich L, Crowell JA, Fay JR. (2003) The epigenome as a target for cancer chemoprevention. J Natl Cancer Inst. Dec 3;95(23):1747-57. Review.
[Abstract on PubMed]
Korytko PJ, Rodvold KA, Crowell JA, Stacewicz-Sapuntzakis M, Diwadkar-Navsariwala V, Bowen PE, Schalch W, Levine BS. (2003) Pharmacokinetics and tissue distribution of orally administered lycopene in male dogs. J Nutr. Sep;133(9):2788-92.
[Abstract on PubMed]
Lee JL, Mukhtar H, Bickers DR, Kopelovich L, Athar M. (2003) Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol Appl Pharmacol. Nov 1;192(3):294-306. Review.
[Abstract on PubMed]
Li M, Ren S, Tilli MT, Flaws JA, Lubet R, Grubbs CJ, Furth PA. (2003) Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity. Oncogene. May 1;22(17):2568-72.
[Abstract on PubMed]
Malone W, Perloff M, Crowell J, Sigman C, Higley H. (2003) Fenretinide: a prototype cancer prevention drug. Expert Opin Investig Drugs. Nov;12(11):1829-42.
[Abstract on PubMed]
Miltyk W, Craciunescu CN, Fischer L, Jeffcoat RA, Koch MA, Lopaczynski W, Mahoney C, Jeffcoat RA, Crowell J, Paglieri J, Zeisel SH. (2003) Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer. Am J Clin Nutr. 77(4):875-82.
[Abstract on PubMed]
Sabichi AL, Xu H, Fischer S, Zou C, Yang X, Steele VE, Kelloff GJ, Lotan R, Clifford JL. (2003) Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites. Clin Cancer Res. Oct 1;9(12):4606-13.
[Abstract on PubMed]
Steele VE.(2003) Current mechanistic approaches to the chemoprevention of cancer. J Biochem Mol Biol. 36(1):78-81.
[Abstract on PubMed]
Steele VE, Hawk ET, Viner JL, Lubet RA. (2003) Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat Res. 523-524:137-44.
[Abstract on PubMed]
Swezey RR, Aldridge DE, LeValley SE, Crowell JA, Hara Y, Green CE. (2003) Absorption, tissue distribution and elimination of 4-[(3)h]-epigallocatechin gallate in beagle dogs. Int J Toxicol. May-Jun;22(3):187-93.
[Abstract on PubMed]
Takimoto CH, Glover K, Huang X, Hayes SA, Gallot L, Quinn M, Jovanovic BD, Shapiro A, Hernandez L, Goetz A, Llorens V, Lieberman R, Crowell JA, Poisson BA, Bergan RC. (2003) Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer. Cancer Epidemiol Biomarkers Prev. Nov;12(11 Pt 1):1213-21.
[Abstract on PubMed]
Wan XS, Zhou Z, Kennedy AR, Kopelovich L. (2003) In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. Oncol Rep. Nov-Dec;10(6):2009-14.
[Abstract on PubMed]
Wan XS, Zhou Z, Steele V, Kopelovich L, Kennedy AR. (2003) Establishment and characterization of sublines of LNCaP human prostate cancer cells. Oncol Rep. Sep-Oct;10(5):1569-75.
[Abstract on PubMed]
Wang Y, Zhang Z, Kastens E, Lubet RA, You M. (2003) Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res. Aug 1;63(15):4389-95.
[Abstract on PubMed]
Wax A, Yang C, Muller MG, Nines R, Boone CW, Steele VE, Stoner GD, Dasari RR, Feld MS. (2003) In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. Cancer Res. Jul 1;63(13):3556-9.
[Abstract on PubMed]
Williams JL, Nath N, Chen J, Hundley TR, Gao J, Kopelovich L, Kashfi K, Rigas B. . (2003) Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention. Cancer Res. Nov 15;63(22):7613-8.
[Abstract on PubMed]
Yang K, Fan K, Kurihara N, Shinozaki H, Rigas B, Augenlicht L, Kopelovich L, Edelmann W, Kucherlapati R, Lipkin M. (2003) Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis 24(3):605-611.
[Abstract on PubMed]
Yao R, Wang Y, Lubet RA, You M. (2003) Differential gene expression in chemically induced mouse lung adenomas. Neoplasia 5(1):41-52.
[Abstract on PubMed]
Zhang Z, Wang Y, Lantry LE, Kastens E, Liu G, Hamilton AD, Sebti SM, Lubet RA, You M. (2003) Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene. Sep 18;22(40):6257-65.
[Abstract on PubMed]
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2002
An KP, Athar M, Tang X, Katiyar SK, Russo J, Beech J, Aszterbaum M, Kopelovich L, Epstein EH Jr, Mukhtar H, Bickers DR. (2002) Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem Photobiol. 76(1):73-80.
[Abstract on PubMed]
Benkins SW, Hockett R Jr., Grizzle W, Weiss, HL, Pickens, A, Perloff, M, Malone, WF, Bland KI. (2002) Transforming growth factor-alpha: a surrogate endpoint biomarker? J Am Coll Surg 195(2):149-158.
[Abstract on PubMed]
Bloedon LT, Jeffcoat AR, Lopaczynski W, Schell MJ, Black TM, Dix KJ, Thomas BF, Albright C, Busby MG, Crowell JA, Zeisel SH. (2002) Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. Am J Clin Nutr. 76(5):1126-37.
[Abstract on PubMed]
Busby MG, Jeffcoat AR, Bloedon LT, Koch MA, Black T, Dix KJ, Heizer WD, Thomas BF, Hill JM, Crowell JA, Zeisel SH. (2002) Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am J Clin Nutr. 75:126-136.
[Abstract on PubMed]
Chen X, Li N, Wang S, Hong J, Fang M, Yousselfson J, Yang P, Newman RA, Lubet RA, Yang CS. (2002) Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. Carcinogenesis 23(12):2095-102.
[Abstract on PubMed]
Christov KT, Moon RC, Lantvit DD, Boone CW, Steele VE, Lubet RA, Kelloff GJ, Pezzuto JM. (2002) 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats. Cancer Res. 15;62(18):5178-82.
[Abstract on PubMed]
Cope MB, Steele VE, Eto I, Juliana MM, Hill DL, Grubbs CJ. (2002) Prevention of methylnitrosourea-induced mammary cancers by 9-cis-retinoic acid and/or vitamin D3. Oncol Rep. 9:533-537.
[Abstract on PubMed]
Elmore E, Siddiqui S, Desai N, Moyer MP, Steele VE, Redpath JL. (2002) The human epithelial cell cytotoxicity assay for determining tissue specific toxicity: method modifications. Methods Cell Sci.;24(4):145-53.
[Abstract on PubMed]
Gunning WT, Kramer PM, Steele VE, Pereira MA. (2002) Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res. 62(15):4199-201.
[Abstract on PubMed]
Katdare M, Kopelovich L, Telang N. (2002) Efficacy of chemopreventive agents for growth inhibition of Apc [+/-] 1638NCOL colonic epithelial cells. (2002) Int J Mol Med. 10(4):427-32.
[Abstract on PubMed]
Kavanaugh CJ, Desai KV, Calvo A, Brown PH, Couldrey C, Lubet R, Green JE. (2002) Pre-clinical applications of transgenic mouse mammary cancer models. Transgenic Res. 11(6):617-33.
[Abstract on PubMed]
Kopelovich L, Fay JR, Glazer RI, Crowell JA. (2002) Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents. Mol Cancer Ther. 1:357-363.
Lee SK, Heo YH, Steele VE, Pezzuto JM. (2002) Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. Anticancer Res. 22:97-102.
[Abstract on PubMed]
Madhukar BV, Dimitrov NV, Meyer-Leece C, Contreras ML, Crowell J. (2002) Inhibition of mitogen-activated protein kinase activity of human lymphocytes after oral administration of Oltipraz. Mol Cancer Ther. 1(12):1125-8.
[Abstract on PubMed]
McDoniels-Silvers AL, Nimri CF, Stoner GD, Lubet RA, You M. (2002) Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res. 8:1127-1138.
[Abstract on PubMed]
McDoniels-Silvers AL, Stoner GD, Lubet RA, You M. (2002) Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues. Neoplasia. 4:141-150.
[Abstract on PubMed]
Misra RR, Hursting SD, Perkins SN, Sathyamoorthy N, Mirsalis JC, Riccio ES, Crowell JA. (2002) Genotoxicity and carcinogenicity studies of soy isoflavones. Int J Toxicol. 21(4):277-85.
[Abstract on PubMed]
Opitz OG, Harada H, Suliman Y, Rhoades B, Sharpless NE, Kent R, Kopelovich L, Nakagawa H, Rustgi AK. (2002) A mouse model of human oral-esophageal cancer. J Clin Invest. 110(6):761-9.
[Abstract on PubMed]
Pereira MA, Li Y, Gunning WT, Kramer PM, Al-Yaqoub F, Lubet RA, Steele VE, Szabo E, Tao L. (2002) Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis. 2002 Jul;23(7):1185-92.
[Abstract on PubMed]
Rodriguez-Burford C, Steele VE, Anderson AS, Stockard CR, Weiss HL, Eto I, Johanning GL, Grizzle WE, Grubbs CJ. (2002) Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology. Nutr Cancer. 43(1):67-75.
[Abstract on PubMed]
Sharma S, Wilkinson BP, Gao P, Steele VE. (2002) Differential Activity of NO Synthase Inhibitors as Chemopreventive Agents in a Primary Rat Tracheal Epithelial Cell Transformation System. Neoplasia. 4:332-336.
[Abstract on PubMed]
Steele VE, Boone CW, Dauzonne D, Rao CV, Bensasson RV. (2002) Correlation between electron-donating ability of a series of 3-nitroflavones and their efficacy to inhibit the onset and progression of aberrant crypt foci in the rat colon. Cancer Res. 62(22):6506-9.
[Abstract on PubMed]
Sutter TR, He XR, Dimitrov P, Xu L, Narasimhan G, George EO, Sutter CH, Grubbs C, Savory R, Stephan-Gueldner M, Kreder D, Taylor MJ, Lubet R, Patterson TA, Kensler TW. (2002) Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents. Mol Cancer TherDec;1(14):1283-92
[Abstract on PubMed]
Tao L, Kramer PM, Wang W, Yang S, Lubet RA, Steele VE, Pereira MA. (2002) Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. Carcinogenesis. 23(9):1447-54.
[Abstract on PubMed]
Tao L, Li Y, Wang W, Kramer PM, Gunning WT, Lubet RA, Steele VE, Pereira MA. (2002) Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors. Mol Carcinog. 35(2):93-102.
[Abstract on PubMed]
Wan XS, Serota DG, Ware JH, Crowell JA, Kennedy AR. (2002) Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate. Nutr. Cancer 43(2):167-73.
[Abstract on PubMed]
Yao R, Wang Y, Lubet RA, You M. (2002) Differentially expressed genes associated with mouse lung tumor progression. Oncogene. 22;21(37):5814-21.
[Abstract on PubMed]
Zhang Z, Li J, Lantry LE, Wang Y, Wiseman RW, Lubet RA, You M. (2002) p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas. Cancer Res. 62:3024-3029.
[Abstract on PubMed]
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2001
Chow HH, Cai Y, Alberts DS, Hakim I, Dorr R, Shahi F, Crowell JA, Yang CS, Hara Y. (2001) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol Biomarkers Prev. 10:53-58.
[Abstract on PubMed]
Clifford JL, Sabichi AL, Zou C, Yang X, Steele VE, Kelloff GJ, Lotan R, Lippman SM. (2001) Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer. Cancer Epidemiol Biomarkers Prev. 10:391-395.
[Abstract on PubMed]
Cohen LA, Zhao Z, Pittman B, Aliaga C, Lubet R. (2001) Feeding thiol-containing compounds, derived from vegetables, fails to inhibit N-methylnitrosourea-induced mammary tumorigenesis. Cancer Detect Prev. 25:254-261.
[Abstract on PubMed]
Crowell JA, Holmes CJ. (2001) Agent identification and preclinical testing. Cancer Treat Res. 106:1-30.
[Abstract on PubMed]
D'Agostini F, Balansky RM, Bennicelli C, Lubet RA, Kelloff GJ, De Flora S. (2001) Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice. Int J Oncol. 18:607-615.
[Abstract on PubMed]
D'Agostini F, Balansky RM, Izzotti A, Lubet RA, Kelloff GJ, De Flora S. (2001) Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats. Carcinogenesis. 22:375-380.
[Abstract on PubMed]
D'Ambrosio SM, Gibson-D'Ambrosio RE, Wani G, Casto B, Milo GE, Kelloff GJ, Steele VE. (2001) Modulation of Ki67, p53 and RARbeta expression in normal, premalignant and malignant human oral epithelial cells by chemopreventive agents. Anticancer Res. 21:3229-3235.
[Abstract on PubMed]
Dimitrov NV, Leece CM, Tompkins ER, Seymour E, Bennink M, Gardiner J, Crowell J, Hawk E, Nashawaty M, Bennett JL. (2001) Oltipraz concentrations in plasma, buccal mucosa cells, and lipids: pharmacological studies. Cancer Epidemiol Biomarkers Prev. 10:201-207.
[Abstract on PubMed]
Elmore E, Luc TT, Steele VE, Redpath JL. (2001) Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia. In Vitr Mol Toxicol. 14:191-207.
[Abstract on PubMed]
Elmore E, Stringer DE, Steele VE, Gerner EW, Redpath JL. (2001) Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation. Anticancer Res. 21:1163-1165.
[Abstract on PubMed]
Fischer SM, Lee M, Lubet RA. (2001) Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice. Carcinogenesis. 22:83-88.
[Abstract on PubMed]
Green JE, Shibata MA, Shibata E, Moon RC, Anver MR, Kelloff G, Lubet R. (2001) 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. Cancer Res. 61:7449-7455.
[Abstract on PubMed]
Gupta A, Nines R, Rodrigo KA, Aziz RA, Carlton PS, Gray DL, Steele VE, Morse MA, Stoner GD. (2001) Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. J Natl Cancer Inst. 93:990-998.
[Abstract on PubMed]
Hebert JL, Khugyani F, Athar M, Kopelovich L, Epstein EH, Jr., Aszterbaum M. (2001) Chemoprevention of basal cell carcinomas in the ptc1+/- mouse--green and black tea. Skin Pharmacol Appl Skin Physiol. 14:358-362.
[Abstract on PubMed]
Herbert BS, Wright AC, Passons CM, Wright WE, Ali IU, Kopelovich L, Shay JW. (2001) Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells. J Natl Cancer Inst. 93:39-45.
[Abstract on PubMed]
Herzog CR, Crist KA, Sabourin CL, Kelloff GJ, Boone CW, Stoner GD, You M. (2001) Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas. Mol Carcinog. 30:159-168.
[Abstract on PubMed]
Hoque A, Lippman SM, Boiko IV, Atkinson EN, Sneige N, Sahin A, Weber DM, Risin S, Lagios MD, Schwarting R, Colburn WJ, Dhingra K, Follen M, Kelloff GJ, Boone CW, Hittelman WN. (2001) Quantitative nuclear morphometry by image analysis for prediction of recurrence of ductal carcinoma in situ of the breast. Cancer Epidemiol Biomarkers Prev. 10:249-259.
[Abstract on PubMed]
Izzotti A, Balansky RM, Dagostini F, Bennicelli C, Myers SR, Grubbs CJ, Lubet RA, Kelloff GJ, De Flora S. (2001) Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer Res. 61:2472-2479.
[Abstract on PubMed]
Johanning GL, Cope MB, Wilborn T, Grubbs CJ, Lubet RA. (2001) Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice. Anticancer Res. 21:1691-1695.
[Abstract on PubMed]
Katdare M, Kopelovich L, Telang N. (2001) Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse. Ann N Y Acad Sci. 952:169-174.
[Abstract on PubMed]
Kelloff GJ, Sigman CC, Hawk ET, Johnson KM, Crowell JA, Guyton KZ. (2001) Surrogate end-point biomarkers in chemopreventive drug development. IARC Sci Publ. 154:13-26.
[Abstract on PubMed]
Kelloff GJ, Lieberman R, Steele VE, Boone CW, Lubet RA, Kopelovich L, Malone WA, Crowell JA, Higley HR, Sigman CC. (2001) Agents, biomarkers, and cohorts for chemopreventive agent development in prostate cancer. Urology. 57:46-51.
[Abstract on PubMed]
Knott KK, McGinley JN, Lubet RA, Steele VE, Thompson HJ. (2001) Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea. Breast Cancer Res Treat. 70:171-183.
[Abstract on PubMed]
Liebes L, Conaway CC, Hochster H, Mendoza S, Hecht SS, Crowell J, Chung FL. (2001) High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. Anal Biochem. 291:279-289.
[Abstract on PubMed]
Lin L, Wang Y, Bergman G, Kelloff GJ, Lubet RA, You M. (2001) Detection of differentially expressed genes in mouse lung adenocarcinomas. Exp Lung Res. 27:217-229.
[Abstract on PubMed]
Mehta RG, Bhat KP, Hawthorne ME, Kopelovich L, Mehta RR, Christov K, Kelloff GJ, Steele VE, Pezzuto JM. (2001) Induction of atypical ductal hyperplasia in mouse mammary gland organ culture. J Natl Cancer Inst. 93:1103-1106.
[Abstract on PubMed]
Newmark HL, Yang K, Lipkin M, Kopelovich L, Liu Y, Fan K, Shinozaki H. (2001) A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis. 22:1871-1875.
[Abstract on PubMed]
Rodriguez-Burford C, Lubet RA, Steele VE, Eto I, Bandy M, Juliana MM, Weiss HL, Grizzle WE, Kelloff GJ, Grubbs CJ. (2001) Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention. Oncol Rep. 8:373-379.
[Abstract on PubMed]
Sharma S, Ghoddoussi M, Gao P, Kelloff GJ, Steele VE, Kopelovich L. (2001) A quantitative angiogenesis model for efficacy testing of chemopreventive agents. Anticancer Res. 21:3829-3837.
[Abstract on PubMed]
Sun SY, Yue P, Kelloff GJ, Steele VE, Lippman SM, Hong WK, Lotan R. (2001) Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells. Cancer Epidemiol Biomarkers Prev. 10:595-601.
[Abstract on PubMed]
Wang Y, Hu L, Yao R, Wang M, Crist KA, Grubbs CJ, Johanning GL, Lubet RA, You M. (2001) Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor. Oncogene. 20:7710-7721.
[Abstract on PubMed]
Weiss HL, Urban DA, Grizzle WE, Cronin KA, Freedman LS, Kelloff GJ, Lieberman R. (2001) Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer. Urology. 57:220-223.
[Abstract on PubMed]
Zujewski J, Vaughn-Cooke A, Flanders KC, Eckhaus MA, Lubet RA, Wakefield LM. (2001) Transforming growth factors-beta are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system. Breast Cancer Res. 3:66-75.
[Abstract on PubMed]
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2000
Arif JM, Gairola CG, Kelloff GJ, Lubet RA, Gupta RC. (2000) Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol. Mutat Res. 452(1):11-18.
[Abstract on PubMed]
Boone CW, Kelloff GJ. (2000) Endpoint markers for cancer chemoprevention trials derived from the lesion of precancer (intraepithelial neoplasia) measured by computer-assisted quantitative image analysis. J Cell Biochem Suppl. 34:67-72. Review.
[Abstract on PubMed]
Boone CW, Stoner GD, Bacus JV, Kagan V, Morse MA, Kelloff GJ, Bacus JW. (2000) Chemoprevention with theaflavins of rat esophageal intraepithelial neoplasia quantitatively monitored by image tile analysis. Cancer Epidemiol Biomarkers Prev. 9(11):1149-54.
[Abstract on PubMed]
Boone CW, Stoner GD, Bacus JV, Kagan V, Morse MA, Kelloff GJ, Bacus JW. (2000) Quantitative grading of rat esophageal carcinogenesis using computer-assisted image tile analysis. Cancer Epidemiol Biomarkers Prev. 9(5):495-500.
[Abstract on PubMed]
Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, Constantinou A. (2000) Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity. Eur J Cancer. 36(16):2146-56.
[Abstract on PubMed]
Chow HH, Earnest DL, Clark D, Mason-Liddil N, Kramer CB, Einspahr JG, Guillen-Rodriguez JM, Roe DJ, Malone W, Crowell JA, Alberts DS. (2000) Effect of subacute ibuprofen dosing on rectal mucosal prostaglandin E2 levels in healthy subjects with a history of resected polyps. Cancer Epidemiol Biomarkers Prev. 9(4):351-6.
[Abstract on PubMed]
Christov K, Shilkaitis A, Green A, Mehta RG, Grubbs C, Kelloff G, Lubet R. (2000) Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole. Breast Cancer Res Treat. 60(2):117-28.
[Abstract on PubMed]
D'Agostini F, Balansky R, Pesce C, Fiallo P, Lubet RA, Kelloff GJ, De Flora S. (2000) Induction of alopecia in mice exposed to cigarette smoke. Toxicol Lett. 114(1-3):117-23.
[Abstract on PubMed]
D'Ambrosio,S.M., D'Ambrosio,R.G., Milo,G.E., Casto,B.C., Kelloff,G.J., Steele,V.E. (2000) Differential responses of normal, premalignant, and malignant human oral epithelial cells by chemopreventive agents. AntiCancer Research 20(4): 2273-2280.
[Abstract on PubMed]
Decensi A, Torrisi R, Bruno S, Costantini M, Curotto A, Nicolo G, Malcangi B, Baglietto L, Bruttini GP, Gatteschi B, Rondanina G, Varaldo M, Perloff M, Malone WF, Bruzzi P. (2000) Randomized trial of fenretinide in superficial bladder cancer using DNA flow cytometry as an intermediate end point. Cancer Epidemiol Biomarkers Prev. Oct;9(10):1071-8.
[Abstract on PubMed]
Elmore E, Luc TT, Li HR, Buckmeier JA, Steele VE, Kelloff GJ, Redpath JL. (2000) Correlation of chemopreventive efficacy data from the human epidermal cell assay with in vivo data. Anticancer Res. 20(1A):27-32.
[Abstract on PubMed]
Elmore E, Luc TT, Steele VE, Kelloff GJ, Redpath JL. (2000) The human epithelial cell cytotoxicity assay for determining tissue specific toxicity. Methods Cell Sci 22(1):17-24.
[Abstract on PubMed]
Grubbs CJ, Lubet RA, Koki AT, Leahy KM, Masferrer JL, Steele VE, Kelloff GJ, Hill DL, Seibert K. (2000) Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats. Cancer Res. 60(20):5599-5602.
[Abstract on PubMed]
Guidi AJ, Berry DA, Broadwater G, Perloff M, Norton L, Barcos MP, Hayes DF. (2000) Association of angiogenesis in lymph node metastases with outcome of breast cancer. J Natl Cancer Inst. Mar 15;92(6):486-92.
[Abstract on PubMed]
Gunning WT, Kramer PM, Lubet RA, Steele VE, Pereira MA.(2000) Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice. Exp Lung Res. 26(8):757-72.
[Abstract on PubMed]
Halberg RB, Katzung DS, Hoff PD, Moser AR, Cole CE, Lubet RA, Donehower LA, Jacoby RF, Dove WF. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A. 97(7):3461-6.
[Abstract on PubMed]
Jacoby RF, Seibert K, Cole CE, Kelloff G, Lubet RA. (2000) The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Cancer Res. 60(18):5040-4.
[Abstract on PubMed]
Hansen LA, Sigman CC, Andreola F, Ross SA, Kelloff GJ, De Luca LM. (2000) Retinoids in chemoprevention and differentiation therapy. Carcinogenesis. 21(7):1271-9.
[Abstract on PubMed]
Jacoby RF, Cole CE, Tutsch K, Newton MA, Kelloff G, Hawk ET, Lubet RA. (2000) Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. Cancer Res. 60(7):1864-70.
[Abstract on PubMed]
Kelloff GJ. (2000) Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res 78:199-334.
[Abstract on PubMed]
Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, Kopelovich L, Hawk ET, Lieberman R, Lawrence JA, Ali I, Viner JL, Sigman CC. (2000) Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr. 130(2S Suppl):467S-471S. Review.
[Abstract on PubMed]
Kelloff GJ, Sigman CC, Johnson KM, Boone CW, Greenwald P, Crowell JA, Hawk ET, Doody LA. (2000) Perspectives on surrogate end points in the development of drugs that reduce the risk of cancer. Cancer Epidemiol Biomarkers Prev. 9(2):127-37. Review.
[Abstract on PubMed]
Lantry LE, Zhang Z, Yao R, Crist KA, Wang Y, Ohkanda J, Hamilton AD, Sebti SM, Lubet RA, You M (2000) Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 21(1):113-6.
[Abstract on PubMed]
Lawrence JA, Malpas PB, Sigman CC, Kelloff GJ. (2000) Clinical development of estrogen modulators for breast cancer chemoprevention in premenopausal vs. postmenopausal women. J Cell Biochem Suppl. 34:103-14. Review.
[Abstract on PubMed]
Liu J, Gu P, Bergman G, Kelloff GJ, Boone CW, You M, Wang Y. (2000) Detection of genetic alterations in mouse lung adenocarcinomas by two-dimensional gel electrophoresis. Exp Lung Res. 26(8):651-8.
[Abstract on PubMed]
Liu Y, Kyle E, Lieberman R, Crowell J, Kelloff G, Bergan RC. (2000) Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-beta-1- integrin complex formation. Clin Exp Metastasis.18(3):203-12.
[View Abstract]
Lantry LE, Zhang Z, Crist KA, Wang Y, Hara M, Zeeck A, Lubet RA, You M. (2000) Chemopreventive efficacy of promising farnesyltransferase inhibitors. Exp Lung Res. 26(8):773-90.
[Abstract on PubMed]
Lubet RA, Zhang Z, Wiseman RW, You M. (2000) Use of p53 transgenic mice in the development of cancer models for multiple purposes. Exp Lung Res. 26(8):581-93. Review.
[Abstract on PubMed]
Reddy BS, Hirose Y, Lubet R, Steele V, Kelloff G, Paulson S, Seibert K, Rao CV. (2000) Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res. 60(2):293-7.
[Abstract on PubMed]
Reddy BS, Hirose Y, Lubet RA, Steele VE, Kelloff GJ, Rao CV. (2000) Lack of chemopreventive efficacy of DL-selenomethionine in colon carcinogenesis. Int J Mol Med. 5(4):327-30.
[Abstract on PubMed]
Shilkaitis A, Green A, Steele V, Lubet R, Kelloff G, Christov, K. (2000) Neoplastic transformation of mammary epithelial cells in rats is associated with decreased apoptotic cell death. Carcinogenesis 21(2):227-233.
[Abstract on PubMed]
Shilkaitis, A., Graves, J., Mehta, R., Hu, L., You, M., Lubet, R., Steele, V., Kelloff, G., Christov, K. (2000) Bcl-2 and Bax are differentially expressed in hyperplastic, premalignant, and malignant lesions of mammary carcinogenesis. Cell Growth & Differentiation 11:437-445.
[Abstract on PubMed]
Singletary E, Lieberman R, Atkinson N, Sneige N, Sahin A, Tolley S, Colchin M, Bevers T, Stelling C, Fornage B, Fritsche H, Hittelman W, Kelloff G, Lippman SM. (2000) Novel translational model for breast cancer chemoprevention study: accrual to a presurgical intervention with tamoxifen and N-[4-hydroxyphenyl] retinamide. Cancer Epidemiol Biomarkers Prev. 9(10):1087-90.
[Abstract on PubMed]
Steele, V.E., Holmes, C.A., Hawk, E.T., Kopelovich, L., Lubet, R.A., Crowell, J.A., Sigman, C.C., and Kelloff, G.J. (2000) Potential use of lipoxygenase inhibitors for cancer chemopreventions. Exp. Opin. Invest. Drugs 9(9):2121-2138.
Steele VE, Kelloff GJ, Balentine D, Boone CW, Mehta R, Bagheri D, Sigman CC, Zhu S, Sharma S. (2000) Comparative chemopreventive mechanisms of green tea, black tea and selected po
