Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183

Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183

Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183

Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183

Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183

Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183

Principal Investigator

Guilherme
Cantuaria
Awardee Organization

Northside Hospital Atlanta
United States

Fiscal Year
2023
Activity Code
UG1
Early Stage Investigator Grants (ESI)
Not Applicable
Project End Date

Georgia NCI Community Oncology Research Program (GA NCORP)

This renewal application is for the statewide Georgia National Cancer Institute (NCI) Community Oncology Research Program (GA NCORP) Community Site, which represents a collaboration between the two largest community oncology clinical trial programs in Georgia, Northside Hospital Cancer Institute in Atlanta and the Nancy N. and J.C. Lewis Cancer & Research Pavilion at St. Joseph's/Candler in Savannah, and the Georgia Center for Oncology Research and Education (Georgia CORE) in Atlanta. Georgia CORE provides network affiliation for five contracted healthcare organizations across Georgia. In 2016, GA NCORP Affiliates together provided care to approximately 17,000 newly diagnosed patients with cancer and enrolled 1,198 patients to NCI-sponsored trials since August 2014. Through an integrated organizational and leadership structure, leading cancer researchers of GA NCORP are poised to build on a 29-year history of collaboration to further enhance the quality of cancer care in Georgia through improved access to NCI-sponsored trials and through the implementation of the goals of GA NCORP. The overall goal of GA NCORP is to bring cancer clinical research studies to individuals in their own communities through a statewide network utilizing shared infrastructure. This approach generates a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities. Four specific aims are proposed to achieve the overall goal of GA NCORP: 1) to increase the number of eligible patients at risk for, or diagnosed with, cancer and who are provided access to, and enroll in, cancer clinical trials within their community; 2) to enroll participants from underrepresented populations across all study types and settings to reduce cancer disparities (populations include racial/ethnic minorities, sexual and gender minorities, adolescents, young adults, elderly, and rural residents); 3) to create a balanced trial portfolio between treatment trials and cancer control and prevention trials; and 4) to increase accrual and expand network-wide participation in cancer care delivery research. Achieving these aims will improve the quality of care in Georgia through increasing cancer research in local communities, identifying best practices for research accruals, and maximizing capacity and expertise for cancer research statewide.

Publications

  • Cleary JM, Wang V, Heist RS, Kopetz ES, Mitchell EP, Zwiebel JA, Kapner KS, Chen HX, Li S, Gray RJ, McShane LM, Rubinstein LV, Patton DR, Meric-Bernstam F, Dillmon MS, Williams PM, Hamilton SR, Conley BA, Aguirre AJ, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT. Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Jun 1;27(11):2996-3004. Epub 2021 Feb 26. PMID: 33637626
  • Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Mar 1;36(7):697-703. Epub 2018 Jan 22. PMID: 29356608
  • Tarhini AA, Lee SJ, Li X, Rao UNM, Nagarajan A, Albertini MR, Mitchell JW Jr, Wong SJ, Taylor MA, Laudi N, Truong PV, Conry RM, Kirkwood JM. E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Jan 15;25(2):524-532. Epub 2018 Nov 12. PMID: 30420448
  • Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM. Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27. PMID: 36166727
  • Owonikoko TK, Redman MW, Byers LA, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Al Baghdadi T, Lara P Jr, Miao J, Kelly K, Ramalingam SS, Herbst RS, Papadimitrakopoulou V, Gandara DR. Phase 2 Study of Talazoparib in Patients With Homologous Recombination Repair-Deficient Squamous Cell Lung Cancer: Lung-MAP Substudy S1400G. Clinical lung cancer. 2021 May;22(3):187-194.e1. Epub 2021 Jan 10. PMID: 33583720
  • Cathcart-Rake E, Novotny P, Leon-Ferre R, Le-Rademacher J, Storrick EM, Adjei AA, Terstriep S, Glaser R, Giuliano A, Mitchell WR, Page S, Austin C, Deming RL, Ferreira MA, Lafky JM, Birrell SN, Loprinzi CL. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 Jan;29(1):387-396. Epub 2020 May 6. PMID: 32372176
  • Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. The Lancet. Oncology. 2018 Jan;19(1):101-114. Epub 2017 Nov 20. PMID: 29169877
  • Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA. A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). Clinical lung cancer. 2021 May;22(3):170-177. Epub 2020 Oct 14. PMID: 33221175
  • West HL, Moon J, Wozniak AJ, Mack P, Hirsch FR, Bury MJ, Kwong M, Nguyen DD, Moore DF, Miao J, Redman M, Kelly K, Gandara DR. Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clinical lung cancer. 2018 Jan;19(1):84-92. Epub 2017 Jul 6. PMID: 28801183